ENTPD5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All ENTPD5 reagents are produced in house and quality controlled, including 7 ENTPD5 Antibody, 2 ENTPD5 ELISA, 28 ENTPD5 Gene, 1 ENTPD5 IP Kit, 2 ENTPD5 Lysate, 2 ENTPD5 Protein, 2 ENTPD5 qPCR. All ENTPD5 reagents are ready to use.

ENTPD5 Protein (2)

    ENTPD5 Antibody (7)

      ENTPD5 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      ENTPD5 cDNA Clone (28)

      NM_001249.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001026214.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ENTPD5 Lysate (2)

        ENTPD5 の背景知識

        Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. It is Up-regulated in PTEN-deficient cells. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation.ENTPD5 promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, ENTPD5 constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. ENTPD5 also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. This enzyme Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

        ENTPD5 の参考文献

        • Villar J, et al. (2009) PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization. Cancer Res. 69(1): 102-10.
        • Fang M, et al. (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell. 143(5): 711-24.
        • Paez JG, et al. (2001) Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene. Int J Oncol. 19(6): 1249-54.

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