ECM1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All ECM1 reagents are produced in house and quality controlled, including 14 ECM1 Antibody, 2 ECM1 ELISA, 39 ECM1 Gene, 2 ECM1 Lysate, 2 ECM1 Protein, 3 ECM1 qPCR. All ECM1 reagents are ready to use.

ECM1 Protein (2)

    ECM1 Antibody (14)

      ECM1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      ECM1 cDNA Clone (39)

      NM_004425.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_007899.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_053882.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ECM1 Lysate (2)

        ECM1 の背景知識

        Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling.

        ECM1 の参考文献

        • Oyama N, et al. (2003) Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet. 362(9378): 118-23.
        • Chan I, et al. (2004) Rapid diagnosis of lipoid proteinosis using an anti-extracellular matrix protein 1 (ECM1) antibody. J Dermatol Sci. 35(2): 151-3.
        • Lupo I, et al. (2005) A novel mutation of the extracellular matrix protein 1 gene (ECM1) in a patient with lipoid proteinosis (Urbach-Wiethe disease) from Sicily. Br J Dermatol. 153(5): 1019-22.
        • Sander CS, et al. (2006) Expression of extracellular matrix protein 1 (ECM1) in human skin is decreased by age and increased upon ultraviolet exposure. Br J Dermatol. 154(2): 218-24.

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