E-Selectin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All E-Selectin reagents are produced in house and quality controlled, including 28 E-Selectin Antibody, 3 E-Selectin ELISA, 52 E-Selectin Gene, 10 E-Selectin Lysate, 10 E-Selectin Protein, 3 E-Selectin qPCR. All E-Selectin reagents are ready to use.

E-Selectin Protein (10)

    E-Selectin Antibody (28)

      E-Selectin ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(3)

      E-Selectin cDNA Clone (52)

      NM_000450.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011345.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_138879.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001094967.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      E-Selectin Lysate (10)

        E-Selectin の背景知識

        E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.

        E-Selectin の参考文献

        • Roldn V, et al. (2003) Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature. Thromb Haemost. 90(6): 1007-20.
        • Kawase J, et al. (2009) Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine. Oncol Rep. 22(6): 1293-7.
        • Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.
        • Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80.

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