DUSP14 Proteins, Antibodies, cDNA Clones Research Reagents

All DUSP14 reagents are produced in house and quality controlled, including 2 DUSP14 Antibody, 34 DUSP14 Gene, 1 DUSP14 Protein, 1 DUSP14 qPCR. All DUSP14 reagents are ready to use.

DUSP14 Protein (1)

    DUSP14 Antibody (2)

      DUSP14 cDNA Clone (34)

      NM_007026.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC000370

      In expression vector

      In lentiviral vector

      XM_006533799.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001079893.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      DUSP14 qPCR Primer (1)

      DUSP14 の背景知識

      Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase 1 / 2 (ERK 1 / 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor Ⅳ. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor Ⅳ effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser / Thr and Tyr residues of MAPKs.

      DUSP14 の参考文献

      • Yoshihara Y, et al. (1996) Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. J Neurobiol. 28 (1): 51-69.
      • Klinger S, et al. (2008) Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes. 57 (3): 584-93.
      • Park JE, et al. (2009) PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 387 (4): 795-9.

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