DR4/TRAIL R1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF10A (TNF Receptor Superfamily Member 10a) is a protein coding gene located on human chromosome 8p21.3. TNFRSF10A is also known as DR4, APO2, CD261, TRAILR1, and TRAILR-1. The human TNFRSF10A gene encodes a 50089 Da protein containing 468 amino acids. The TNFRSF10A protein is ubiquitously expressed in lymph node, appendix and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. TNFRSF10A is related to transcription factor binding and protease binding. TNFRSF10B is an important paralog of TNFRSF10A gene. TNFRSF10A is associated with some diseases, including Hirata Disease and Temporal Arteritis.

DR4/TRAIL R1 Protein (3)

    DR4/TRAIL R1 Antibody (10)

      DR4/TRAIL R1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      DR4/TRAIL R1 cDNA Clone (15)


      クローニングベクター cDNA 製品

      In lentiviral vector


      In expression vector

      In lentiviral vector

      DR4/TRAIL R1 qPCR Primer (1)

      DR4/TRAIL R1 Lysate (3)

        DR4/TRAIL R1 の背景知識

        Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

        DR4/TRAIL R1 の参考文献

        • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
        • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.

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