DNase I Proteins, Antibodies, cDNA Clones Research Reagents

All DNase I reagents are produced in house and quality controlled, including 2 DNase I Antibody, 27 DNase I Gene, 1 DNase I Lysate, 1 DNase I Protein, 1 DNase I qPCR. All DNase I reagents are ready to use.

DNase I Protein (1)

    DNase I Antibody (2)

      DNase I cDNA Clone (27)

      BC029437

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010061.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013097.2

      クローニングベクター cDNA 製品

      DNase I qPCR Primer (1)

      DNase I Lysate (1)

        DNase I の背景知識

        DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.

        DNase I の参考文献

        • Shak S. et al., 1991, Proc Natl Acad Sci. 87 (23): 9188-92.
        • Yasutomo K. et al., 2001, Nat Genet. 28 (4): 313-4.
        • Hakkim A. et al., 2010, Proc Natl Acad Sci. 107 (21): 9813-8.

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