DKKL1 Proteins, cDNA Clones Research Reagents

All DKKL1 reagents are produced in house and quality controlled, including 26 DKKL1 Gene, 1 DKKL1 Lysate, 1 DKKL1 Protein, 1 DKKL1 qPCR. All DKKL1 reagents are ready to use.

DKKL1 Protein (1)

    DKKL1 cDNA Clone (26)

    NM_014419.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_015789.3
    NM_001109145.1

    クローニングベクター cDNA 製品

    DKKL1 qPCR Primer (1)

    DKKL1 Lysate (1)

      DKKL1 の背景知識

      Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / placental lineage. This glycoprotein is secreted by postmeiotic male germ cells. DKKL1 is a member of the Dickkopf (DKK) family, a group of proteins that are characterized as secreted antagonists of Wnt signal transduction proteins. In mammals, embryos lacking DKKL1 protein developed into viable, fertile adults. DKKL1, either directly or indirectly, facilitates the ability of sperm to penetrate the zona pellucid. DKKL1 is related to the sperm apoptotic procession. Molecular analyses identified the Fas death ligand (FasL) as a target for DkkL1 pro-apoptotic activity in adult mice. DKKL1 is considered as a negative regulator of adult testic homeostasis and identifies a novel, DKKL1 / FasL- dependent, regulation that specifically controls the number of postpubertal spermatocytes.

      DKKL1 の参考文献

      • Niehrs C. (2006) Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 25 (57): 7469-81.
      • Kohn MJ, et al. (2010) The Acrosomal Protein Dickkopf-Like 1 (DKKL1) Facilitates Sperm Penetration Of The Zona Pellucida. Fertil Steril. 93 (5): 1533-7.
      • KOHN MJ, et al. (2005) DKKL1 (Soggy), A Dickkopf Family Member, Localizes to the Acrosome During Mammalian Spermatogenesis. Mol Reprod Dev. 71 (4): 516-22.

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