Dectin-2 Proteins, Antibodies, cDNA Clones Research Reagents

All Dectin-2 reagents are produced in house and quality controlled, including 1 Dectin-2 Antibody, 13 Dectin-2 Gene, 2 Dectin-2 Lysate, 2 Dectin-2 Protein, 2 Dectin-2 qPCR. All Dectin-2 reagents are ready to use.

Dectin-2 Protein (2)

    Dectin-2 Antibody (1)

      Dectin-2 cDNA Clone (13)

      NM_001007033.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Dectin-2 Lysate (2)

        Dectin-2 の背景知識

        C-type lectin domain family 4 member N (CLEC4N), also known as Dectin-2, is a C-type lectin expressed by dendritic cells (DCs) and macrophages. Members of the C-type lectin domain (CTLD) superfamily are metazoan proteins functionally important in glycoprotein metabolism, mechanisms of multicellular integration and immunity. They share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp family was essentially formed early in vertebrate evolution and is completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates. Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation. Dectin-2 constitutes a major fungal pattern recognition receptor (PRR) that can couple to the Syk-CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

        Dectin-2 の参考文献

        • Robinson MJ, et al. (2009) Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med. 206(9): 2037-51.
        • Saijo S, et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 32(5): 681-91.

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