DCXR Proteins, Antibodies, cDNA Clones Research Reagents

All DCXR reagents are produced in house and quality controlled, including 1 DCXR Antibody, 13 DCXR Gene, 1 DCXR IP Kit, 1 DCXR Protein, 1 DCXR qPCR. All DCXR reagents are ready to use.

DCXR Protein (1)

    DCXR Antibody (1)

      DCXR cDNA Clone (13)

      BC001470

      クローニングベクター cDNA 製品

      In lentiviral vector

      DCXR qPCR Primer (1)

      DCXR の背景知識

      DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

      DCXR の参考文献

      • Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.
      • Pierce SB, et al. (2011) Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria. Proc Natl Acad Sci. 108(45):18313-7.
      • Udeshi ND, et al. (2012) Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol Cell Proteomics. 11(5):148-59.

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