DCUN1D1 Proteins, Antibodies, cDNA Clones Research Reagents

All DCUN1D1 reagents are produced in house and quality controlled, including 1 DCUN1D1 Antibody, 30 DCUN1D1 Gene, 1 DCUN1D1 IP Kit, 1 DCUN1D1 Protein, 1 DCUN1D1 qPCR. All DCUN1D1 reagents are ready to use.

DCUN1D1 Protein (1)

    DCUN1D1 Antibody (1)

      DCUN1D1 cDNA Clone (30)

      BC009478

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001205361.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      DCUN1D1 qPCR Primer (1)

      DCUN1D1 の背景知識

      DCUN1D1, also known as SCCRO, is part of an E3 ubiquitin ligase complex for neddylation. DCUN1D1 functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. DCUN1D1 binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation in reactions using purified recombinant proteins. DCUN1D1 also recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation in purified protein assays. DCUN1D1 also acts as am ncogene facilitating malignant transformation and carcinogenic progression.

      DCUN1D1 の参考文献

      • Heir P. et al., 2013, Mol Cell Biol. 33 (8): 1621-31.
      • Kurz T. et al., 2005, Nature. 435 (7046): 1257-61.
      • Kim AY. et al., 2008, J Biol Chem. 283 (48): 33211-20.

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