DCLK1 Proteins, Antibodies Research Reagents

All DCLK1 reagents are produced in house and quality controlled, including 2 DCLK1 Antibody, 2 DCLK1 Lysate, 2 DCLK1 Protein, 1 DCLK1 qPCR. All DCLK1 reagents are ready to use.

DCLK1 Protein (2)

    DCLK1 Antibody (2)

      DCLK1 qPCR Primer (1)

      DCLK1 Lysate (2)

        DCLK1 の背景知識

        DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.

        DCLK1 の参考文献

        • Sossey-Alaoui K, et al. (1999) DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). Genomics. 56 (1): 121-6.
        • Matsumoto N, et al. (1999) Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). Genomics. 56 (2): 179-83.
        • Lin PT, et al. (2001) DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J Neurosci. 20 (24): 9152-61.

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