DAP10 Proteins, cDNA Clones Research Reagents

HCST (Hematopoietic Cell Signal Transducer, also known as DAP10; KAP10; PIK3AP), located on 19q13.12, is a Protein Coding gene. The gene produces a 9489 Da protein composed of 93 amino acids. HCST is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. Diseases such as Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 are associated with HCST.

DAP10 Protein (1)

    DAP10 cDNA Clone (13)

    BC035931

    クローニングベクター cDNA 製品

    In lentiviral vector

    DAP10 qPCR Primer (1)

    DAP10 Lysate (1)

      DAP10 の背景知識

      HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. HCST may be part of the immune recognition receptor complex. This receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs). It may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif.

      DAP10 の参考文献

      • Wu J. et al., 1999, Science. 285 (5428): 730-2.
      • Karimi M. et al., 2006, J Immunol. 175 (12): 7819-28.
      • André P. et al., 2004, Eur J Immunol. 34 (4): 961-71.

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