Cytokeratin 8 Antibodies, cDNA Clones Research Reagents

KRT8 (Keratin 8, also known as K8; KO; CK8; CK-8; CYK8; K2C8; CARD2), located on 12q13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 53704 Da protein composed of 483 amino acids. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Diseases such as Liver Cirrhosis and Cryptogenic Cirrhosis are associated with KRT8. The related pathways of KRT8 include Cytoskeleton remodeling Neurofilaments and Signaling mediated by p38-alpha and p38-beta.

Cytokeratin 8 Antibody (4)

    Cytokeratin 8 cDNA Clone (31)

    NM_002273.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031170.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_199370.1

    クローニングベクター cDNA 製品

    Cytokeratin 8 qPCR Primer (1)

    Cytokeratin 8 の背景知識

    KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis.

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