Cytokeratin 7/KRT7 Antibodies, cDNA Clones Research Reagents

KRT7 (Keratin 7, also known as K7; CK7; SCL; K2C7), located on 12q13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 51386 Da protein composed of 469 amino acids. The protein encoded by this gene is a member of the keratin gene family. Diseases such as Pseudomyxoma Peritonei and Signet Ring Cell Adenocarcinoma are associated with KRT7. The related pathways of KRT7 include Cytoskeleton remodeling Neurofilaments and Developmental Biology.

Cytokeratin 7/KRT7 Antibody (6)

    Cytokeratin 7/KRT7 cDNA Clone (18)

    NM_005556.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_033073.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_003754353.2

    クローニングベクター cDNA 製品

    Cytokeratin 7/KRT7 の背景知識

    KRT7 (Keratin 7) is a Protein Coding gene. The protein encoded by this gene is a member of the keratin gene family. One AS, designated Homo sapiens keratin 7 (KRT7-AS), was selected due to its marked upregulation and concordant expression with its cognate sense counterpart, KRT7, in GC tissues and cell lines. KRT7-AS formed an RNA-RNA hybrid with KRT7 and controlled KRT7 expression at both the mRNA and the post-transcriptional levels. Moreover, forced overexpression of the KRT7-overlapping region (OL) of KRT7-AS (but not its non-KRT7-OL portions) increased keratin 7 protein levels in cells. Finally, forced overexpression of full-length KRT7-AS or OL KRT7-AS (but not its non-KRT7-OL regions) promoted GC cell proliferation and migration.

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