Cytokeratin 19/KRT19 Antibodies, cDNA Clones Research Reagents

KRT19 (Keratin 19, also known as K19; CK19; K1CS), located on 17q21.2, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. The gene produces a 44106 Da protein composed of 400 amino acids. The protein encoded by this gene is a member of the keratin family. Diseases such as Breast Cancer and Cholangiolocellular Carcinoma are associated with KRT19. The related pathways of KRT19 include Cytoskeleton remodeling Neurofilaments and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

Cytokeratin 19/KRT19 Antibody (5)

    Cytokeratin 19/KRT19 cDNA Clone (45)

    NM_002276.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008471.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_199498.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    Cytokeratin 19/KRT19 の背景知識

    Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression is frequently altered in renal cell carcinoma (RCC).KRT19 was identified as one of the key biomarkers for distinguishing cholangiocarcinoma (CCA) and hepatocellular carcinoma. Expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, knockdown of KRT19 led to increased proliferation, migration, invasion, drug resistance, and sphere formation in breast cancer cells via an upregulated NOTCH signaling pathway.

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