CTRL Proteins, cDNA Clones Research Reagents

All CTRL reagents are produced in house and quality controlled, including 39 CTRL Gene, 1 CTRL Lysate, 1 CTRL Protein, 1 CTRL qPCR. All CTRL reagents are ready to use.

CTRL Protein (1)

    CTRL cDNA Clone (39)

    BC063475

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_023182.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_005592301.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    CTRL qPCR Primer (1)

    CTRL Lysate (1)

      CTRL の背景知識

      CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. Five structurally distinct inhibitors that are known to inhibit chymotrypsin-like proteases were partially protective. They might represent a novel class of drugs with benefit in diseases where overactivity of microglia contributes to the pathogenesis.

      CTRL の参考文献

      • Yang Gu. et al., 2009, Reprod Sci. 16 (9): 905-13.
      • Klegeris A. et al., 2005, Glia. 51 (1):56-64.
      • Caroline V. Bamford. et al., 2007, nfect Immun. 75 (9): 4364-72.

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