CRIP2 Proteins, Antibodies, cDNA Clones Research Reagents

All CRIP2 reagents are produced in house and quality controlled, including 3 CRIP2 Antibody, 31 CRIP2 Gene, 2 CRIP2 Lysate, 2 CRIP2 Protein, 2 CRIP2 qPCR. All CRIP2 reagents are ready to use.

CRIP2 Protein (2)

    CRIP2 Antibody (3)

      CRIP2 cDNA Clone (31)

      NM_001270837.1

      In expression vector

      NM_024223.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_022501.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CRIP2 qPCR Primer (2)

      CRIP2 Lysate (2)

        CRIP2 の背景知識

        CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.

        CRIP2 の参考文献

        • Chang DF. et al., 2003, Dev Cell. 4 (1):107-18.
        • Huber A. et al., 2000, J Biol Chem. 275 (8): 5504-11.
        • Karim MA. et al., 1996, Genomics. 31 (2): 167-76.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.