CPLX3 Proteins, Antibodies, cDNA Clones Research Reagents

All CPLX3 reagents are produced in house and quality controlled, including 1 CPLX3 Antibody, 15 CPLX3 Gene, 1 CPLX3 Lysate, 1 CPLX3 Protein, 1 CPLX3 qPCR. All CPLX3 reagents are ready to use.

CPLX3 Protein (1)

    CPLX3 Antibody (1)

      CPLX3 cDNA Clone (15)

      BC018026

      クローニングベクター cDNA 製品

      In lentiviral vector

      CPLX3 qPCR Primer (1)

      CPLX3 Lysate (1)

        CPLX3 の背景知識

        CPLX3, also known as complexin 3, belongs to the complexin/synaphin family. As a SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma. CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state. Specifically, the central helix of CPX allows SNAREs to form this intermediate energetic state at 9-15 nm but not when the bilayers are closer than 9 nm. Stabilizing the activated-clamped state at separations of less than 9 nm requires the accessory helix of CPX, which prevents membrane-proximal assembly of SNAREpins. CPLX3 binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

        CPLX3 の参考文献

        • Newton-Cheh C. et al., 2009, Nat Genet. 41(6): 666-76.
        • Li F. et al., 2011, Nat Struct Mol Biol. 18 (8): 941-6.
        • Amin N. et al., 2012, Mol Psychiatry. 17 (11): 1116-29.

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