COX-2 Proteins, Antibodies, cDNA Clones Research Reagents

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) is a protein coding gene located on human chromosome 1q31.1. PTGS2 is also known as COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2 and GRIPGHS. The human PTGS2 gene encodes a 68996 Da protein containing 604 amino acids. The PTGS2 protein is biasedly expressed in bone marrow, urinary bladder and other tissues. Among its related pathways are Neuroscience and GABAergic synapse. PTGS2 is related to protein homodimerization activity and lipid binding. PTGS1 is an important paralog of PTGS2 gene. PTGS2 is associated with some diseases, including Gastric Ulcer and Bursitis.

COX-2 Protein (1)

    COX-2 Antibody (1)

      COX-2 cDNA Clone (15)

      NM_000963

      クローニングベクター cDNA 製品

      In lentiviral vector

      COX-2 qPCR Primer (1)

      COX-2 Lysate (1)

        COX-2 の背景知識

        PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

        COX-2 の参考文献

        • Picot, et al. (1994) The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367(6460):243-9.
        • Xie W, et al. (1991) Expression of a Mitogen-Responsive Gene Encoding Prostaglandin Synthase is Regulated by mRNA Splicing. Proceedings of the National Academy of Sciences. 88(7):2692-6.
        • Hla T, et al. (1992) Human Cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences. 89(16):7384-8.

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