Coronavirus Nucleocapsid Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly, and plays a critical role in enhancing the efficiency of virus transcription and assembly. The N protein packages the viral genomic RNA to form the helical nucleocapsid that is incorporated into the budding particle but also fulfills additional roles during the viral infection. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch.

All Coronavirus Nucleocapsid Reagents

Coronavirus Nucleocapsid Antibody (37)

    Coronavirus Nucleocapsid ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

    Coronavirus Nucleocapsid cDNA Clone (17)

    SARS-CoV,Strain Tor2

    In expression vector

    In lentiviral vector

    2019-nCoV

    In expression vector

    SARS-CoV-2

    In lentiviral vector

    MERS-CoV

    In expression vector

    Coronavirus Nucleocapsid Lysate (4)

      Coronavirus Nucleocapsid の背景知識

      Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

      Coronavirus Nucleocapsid の参考文献

        1. 1.Van Boheemen S, et al. (2012), MBio. 3(6):e00473-12.
        2. Bisht H. et al., 2004, Proc Natl Acad Sci. 101 (17): 6641-6.
        3. Li W. et al., 2005, Science. 309 (5742): 1864-8.

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