CNTN4 Proteins, Antibodies, cDNA Clones Research Reagents

All CNTN4 reagents are produced in house and quality controlled, including 2 CNTN4 Antibody, 26 CNTN4 Gene, 2 CNTN4 Lysate, 2 CNTN4 Protein, 2 CNTN4 qPCR. All CNTN4 reagents are ready to use.

CNTN4 Protein (2)

    CNTN4 Antibody (2)

      CNTN4 cDNA Clone (26)

      NM_175607.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001109749.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CNTN4 Lysate (2)

        CNTN4 の背景知識

        Contactin-4, abbreviated as CNTN4, is a brain-derived protein belonging to the immunoglobulin superfamily. It has been found high expression in testes, thyroid, small intestine, uterus and brain. This protein is an neuronal membrane protein that functions as an glycosylphosphatidylinositol- anchored cell adhesion molecule. Contactin-4 is considered as a candidate protein responsible for the differentiation potential of human neuroblastoma cells and it has been implicated in some cases of autism and spinocerebellar ataxia type 16. Studies of the cantactin family have revealed a complex pattern of hemophilic and heterophilic interactions that are required for axon growth and pathfinding. Such studies demonstrate that these essential functions are mediated by the combination and juxtaposition of multiple Ig and FNIII domains. Second, these neuronal adhesion molecules demonstrate highly regulated temporal and spatial expression patterns in the CNS. For this reason, the disruption of the regulatory region of the predominant brain-expressed isoform reasonable would be expected to have significant functional consequences.

        CNTN4 の参考文献

        • Zeng L, et al. (2002) A novel splice variant of the cell adhesion molecule contactin 4 ( CNTN4) is mainly expressed in human brain. J Hum Genet. 47 (9): 497-9.
        • Thomas Fernandez, et al. (2004) Disruption of Contactin 4 (CNTN4) Results in Developmental Delay and Other Features of 3p Deletion Syndrome. Am J Hum Genet. 74 (6): 1286-93.
        • Yoshihara Y, et al. (1996) Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. J Neurobiol. 28 (1): 51-69.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.