CLPS Proteins, Antibodies, cDNA Clones Research Reagents

All CLPS reagents are produced in house and quality controlled, including 5 CLPS Antibody, 54 CLPS Gene, 2 CLPS Lysate, 2 CLPS Protein, 2 CLPS qPCR. All CLPS reagents are ready to use.

CLPS Protein (2)

    CLPS Antibody (5)

      CLPS cDNA Clone (54)

      BC007061

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_025469.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013139.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001116700.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CLPS qPCR Primer (2)

      CLPS Lysate (2)

        CLPS の背景知識

        Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.

        CLPS の参考文献

        • Davis RC, et al. (1991) Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Genomics. 10(1):262-5.
        • Lowe ME. (1997) Structure and function of pancreatic lipase and colipase. Annu Rev Nutr. 17: 141-58.
        • Verger R, et al. (1999) Colipase: structure and interaction with pancreatic lipase. Biochim Biophys Acta. 1441(2-3):173-84.

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