CLK3 Proteins, cDNA Clones Research Reagents

All CLK3 reagents are produced in house and quality controlled, including 30 CLK3 Gene, 1 CLK3 Lysate, 1 CLK3 Protein, 1 CLK3 qPCR. All CLK3 reagents are ready to use.

CLK3 Protein (1)

    CLK3 cDNA Clone (30)

    NM_003992.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_007713.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    CLK3 qPCR Primer (1)

    CLK3 Lysate (1)

      CLK3 の背景知識

      Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity kinases (termed Lammer kinases) that have been conserved in evolution. CLK family members have shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. The three members of the CLK family of kinases (CLK1, CLK2, and CLK3) have been shown to undergo conserved alternative splicing to generate catalytically active and inactive isoforms. The human CLK2 and CLK3 are found within the nucleus and display dual-specificity kinase activity. The truncated isoforms, hCLK2(T) and hCLK3(T), colocalize with SR proteins in nuclear speckles. CLK3 may play a role in the development and progression of azoospermia.

      CLK3 の参考文献

      • Duncan, PI. et al., 1998, Exp. Cell Res. 241: 300 - 8.
      • Menegay, H. et al., 1999, Exp Cell Res. 253 (2): 463-73.
      • García-Sacristán, A. et al., 2005, Cell Res. 15 (7): 495-503.
      • Bullock, AN. et al., 2009, Structure  17 (3): 352-62.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.