CLCA1 Antibodies, cDNA Clones Research Reagents

All CLCA1 reagents are produced in house and quality controlled, including 1 CLCA1 Antibody, 15 CLCA1 Gene, 1 CLCA1 qPCR. All CLCA1 reagents are ready to use.

CLCA1 Antibody (1)

    CLCA1 cDNA Clone (15)

    NM_001285.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001107449.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    CLCA1 qPCR Primer (1)

    CLCA1 の背景知識

    The chloride channel calcium-activated (CLCA) family are secreted proteins that regulate both chloride transport and mucin expression, thus controlling the production of mucus in respiratory and other systems. Accordingly, human CLCA1 is a critical mediator of hypersecretory lung diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, that manifest mucus obstruction. The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunctional signaling protein, including cellular differentiation pathways and induction of mucus production. Specifically, CLCA1 has recently been shown to modulate early immune responses by regulation of cytokines. Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.