CLCA1 Antibodies, cDNA Clones Research Reagents

All CLCA1 reagents are produced in house and quality controlled, including 1 CLCA1 Antibody, 15 CLCA1 Gene, 1 CLCA1 qPCR. All CLCA1 reagents are ready to use.

CLCA1 Antibody (1)

    CLCA1 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector


    クローニングベクター cDNA 製品

    In lentiviral vector

    CLCA1 qPCR Primer (1)

    CLCA1 の背景知識

    The chloride channel calcium-activated (CLCA) family are secreted proteins that regulate both chloride transport and mucin expression, thus controlling the production of mucus in respiratory and other systems. Accordingly, human CLCA1 is a critical mediator of hypersecretory lung diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, that manifest mucus obstruction. The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunctional signaling protein, including cellular differentiation pathways and induction of mucus production. Specifically, CLCA1 has recently been shown to modulate early immune responses by regulation of cytokines. Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix.

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