CK2 alpha/CSNK2A1 Proteins, Antibodies, cDNA Clones Research Reagents

All CK2 alpha/CSNK2A1 reagents are produced in house and quality controlled, including 2 CK2 alpha/CSNK2A1 Antibody, 47 CK2 alpha/CSNK2A1 Gene, 1 CK2 alpha/CSNK2A1 IP Kit, 3 CK2 alpha/CSNK2A1 Lysate, 3 CK2 alpha/CSNK2A1 Protein, 2 CK2 alpha/CSNK2A1 qPCR. All CK2 alpha/CSNK2A1 reagents are ready to use.

CK2 alpha/CSNK2A1 Protein (3)

    CK2 alpha/CSNK2A1 Antibody (2)

      CK2 alpha/CSNK2A1 cDNA Clone (47)

      NM_001895.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_007788.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_006235220.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001260877.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CK2 alpha/CSNK2A1 Lysate (3)

        CK2 alpha/CSNK2A1 の背景知識

        Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

        CK2 alpha/CSNK2A1 の参考文献

        • Schlpfer J, et al. (1997) A radiation hybrid framework map of bovine chromosome 13. Chromosome Res. 5(8): 511-9.
        • Wirkner U, et al. (1994) The human gene (CSNK2A1) coding for the casein kinase II subunit alpha is located on chromosome 20 and contains tandemly arranged Alu repeats. Genomics. 19(2): 257-65.
        • Wirkner U, et al. (1998) Genomic organization and promoter identification of the human protein kinase CK2 catalytic subunit alpha (CSNK2A1). Genomics. 48(1): 71-8.

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