CHUK Antibodies, cDNA Clones Research Reagents

CHUK (Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex, also known as IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha), located on 10q24.31, is a Protein Coding gene. It is ubiquitously expressed in diverse types of established cell lines, whereas it is differentially expressed in normal murine tissues. The encoded protein, a component of a cytokine-activated protein complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquitination pathway. The non-canonical NF-κB activating kinase IKKα, encoded by CHUK, modulates pro- or anti-inflammatory responses, cellular survival, and cellular differentiation.

CHUK Antibody (2)

    CHUK cDNA Clone (2)

    NM_001278.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    CHUK の背景知識

    CHUK (conserved helix-loop-helix ubiquitous kinase) is ubiquitously expressed in diverse types of established cell lines, whereas it is differentially expressed in normal murine tissues. The structural features of the CHUK polypeptide suggest that its putative kinase activity may be targetted to H-L-H and/or leucine zipper transcription factors. Alternatively, the dual amphipathic a-helices may serve to control its intrinsic kinase activity by interactions with other cellular factors. CHUK may provide new insights into the regulated transmission of cytoplasmic signals to specific nuclear factors manifesting rapid alterations in patterns of cellular gene expression. The non-canonical NF-κB activating kinase IKKα, encoded by CHUK, modulates pro- or anti-inflammatory responses, cellular survival, and cellular differentiation. CHUK has an essential role in the development of the skin epidermis and its derivatives, along with various other morphogenetic events.

    CHUK の参考文献

    • Olivotto E, et al. (2013) Ikkα/chuk regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PLoS One 8 (9): e73024.
    • Lahtela J, et al. (2010) Mutant chuk and severe fetal encasement malformation. N Engl J Med 363 (17): 1631-1637.
    • Culley KL, et al. (2019) Inducible knockout of chuk/ikkα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. Sci Rep 9 (1): 8905.
    • Connelly MA, et al. (1995) Chuk, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell Mol Biol Res 41 (6): 537-549.

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