CES3 Antibodies, cDNA Clones Research Reagents

All CES3 reagents are produced in house and quality controlled, including 5 CES3 Antibody, 13 CES3 Gene, 1 CES3 qPCR. All CES3 reagents are ready to use.

CES3 Antibody (5)

    CES3 cDNA Clone (13)


    クローニングベクター cDNA 製品

    In lentiviral vector

    CES3 qPCR Primer (1)

    CES3 の背景知識

    Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to thetype-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.

    CES3 の参考文献

    • Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37.
    • Saito S. et al., 2003, J. Hum. Genet. 48: 249-70.
    • Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91.
    • Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11.
    • Chen R. et al., 2009, J Proteome Res. 8: 651-61.

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