CDK2AP2 Proteins, Antibodies, cDNA Clones Research Reagents

All CDK2AP2 reagents are produced in house and quality controlled, including 2 CDK2AP2 Antibody, 17 CDK2AP2 Gene, 1 CDK2AP2 Protein. All CDK2AP2 reagents are ready to use.

CDK2AP2 Protein (1)

    CDK2AP2 Antibody (2)

      CDK2AP2 cDNA Clone (17)

      NM_005851.4

      クローニングベクター cDNA 製品

      NM_026373.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001109498.1

      クローニングベクター cDNA 製品

      CDK2AP2 の背景知識

      CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.

      CDK2AP2 の参考文献

      • Stelzl U, et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122(6):957-68.
      • 2 Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.
      • 3 Buajeeb W, et al. (2004) Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). Biochem Biophys Res Commun. 315(4):998-1003

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