CDK2AP2 Proteins, Antibodies, cDNA Clones Research Reagents

All CDK2AP2 reagents are produced in house and quality controlled, including 2 CDK2AP2 Antibody, 17 CDK2AP2 Gene, 1 CDK2AP2 Protein. All CDK2AP2 reagents are ready to use.

CDK2AP2 Protein (1)

    CDK2AP2 Antibody (2)

      CDK2AP2 cDNA Clone (17)


      クローニングベクター cDNA 製品


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      CDK2AP2 の背景知識

      CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.

      CDK2AP2 の参考文献

      • Stelzl U, et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122(6):957-68.
      • 2 Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.
      • 3 Buajeeb W, et al. (2004) Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). Biochem Biophys Res Commun. 315(4):998-1003

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