CD97 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

ADGRE5 (Adhesion G Protein-Coupled Receptor E5) is a protein coding gene located on human chromosome 19p13.12. ADGRE5 is also known as CD97 and TM7LN1. The human ADGRE5 gene encodes a 91869 Da protein containing 835 amino acids. The ADGRE5 protein is broadly expressed in bone marrow, spleen and other tissues. Among its related pathways are Signaling by GPCR and Innate Immune System. ADGRE5 is related to G protein-coupled receptor activity and transmembrane signaling receptor activity. ADGRE2 is an important paralog of ADGRE5 gene. ADGRE5 is associated with some diseases, including Vibratory Urticaria and Thyroid Gland Anaplastic Carcinoma.

CD97 Protein (2)

    CD97 Antibody (15)

      CD97 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      CD97 cDNA Clone (29)

      NM_001784.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_078481.2

      クローニングベクター cDNA 製品

      In expression vector

      In lentiviral vector

      AF146344.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD97 Lysate (2)

        CD97 の背景知識

        The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD97 is a receptor predominantly expressed in leukocytes and belongs to a new group of seven-span transmembrane molecules, which is also designed EGF-TM7 family. The family members are characterized by an extended extracellular region with several N-terminal epidermal growth factor-like domains two of which contain a calcium-binding site. Mature CD 97 has two noncovalently associated subunits and is composed of a large extracellular protein (CD97 alpha) and a seven-membrane spanning protein (CD97 beta). CD97 is considered as a defining feature of G protein-coupled receptors. The effects that lymphocytes and erythrocytes adhere to CD97-transfected COS cells suggest that CD97 has the ability to bind cellular ligands. CD97 alpha has three alternatively spliced isoforms that are related to the calcium-binding EGF-like repeats in the microfibril protein fibrillin. Leukocytes strongly positive for CD97 are concentrated at sites of inflammation relative to CD97 expression in normal lymphoid tissues.

        CD97 の参考文献

        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Gray JX, et al. (1996) CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. The journal of Immunology. 157 (12): 5438-47.
        • Hamann J,et al. (1998) Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97.European Journal of Immunology. 28 (5): 1701-7.

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