CD59 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD59 reagents are produced in house and quality controlled, including 24 CD59 Antibody, 2 CD59 ELISA, 39 CD59 Gene, 2 CD59 IP Kit, 4 CD59 Lysate, 4 CD59 Protein, 2 CD59 qPCR. All CD59 reagents are ready to use.

CD59 Protein (4)

    CD59 Antibody (24)

      CD59 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      CD59 cDNA Clone (39)

      NM_203331.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012925.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001083003.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD59 Lysate (4)

        CD59 の背景知識

        CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

        CD59 の参考文献

        • Fletcher CM. et al., 1994, Structure. 2: 185-99.
        • Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
        • Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
        • Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
        • Picariello G. et al., 2008, Proteomics 8: 3833-47.
        • Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.

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