CD40 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD40 reagents are produced in house and quality controlled, including 28 CD40 Antibody, 2 CD40 ELISA, 44 CD40 Gene, 1 CD40 IP Kit, 14 CD40 Lysate, 22 CD40 Protein, 3 CD40 qPCR. All CD40 reagents are ready to use.

CD40 Protein (22)

    CD40 Antibody (28)

      CD40 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      CD40 cDNA Clone (44)

      NM_001250.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_152854.2

      In lentiviral vector

      NM_011611.2

      In expression vector

      NM_134360.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_005569218.2

      In expression vector

      XM_001104333.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_214194.1

      In expression vector

      XM_002721199.3

      In expression vector

      CD40 Lysate (14)

        CD40 の背景知識

        CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

        CD40 の参考文献

        • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
        • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
        • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
        • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
        • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

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