CD300A Proteins, Antibodies, cDNA Clones Research Reagents

All CD300A reagents are produced in house and quality controlled, including 6 CD300A Antibody, 27 CD300A Gene, 3 CD300A Lysate, 3 CD300A Protein, 3 CD300A qPCR. All CD300A reagents are ready to use.

CD300A Protein (3)

    CD300A Antibody (6)

      CD300A cDNA Clone (27)


      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      CD300A Lysate (3)

        CD300A の背景知識

        CMRF35-like molecule 8, also known as CD3 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 6, NK inhibitory receptor, CD3a and CMRF35H, is a single-pass type I membrane protein which belongs to theCD3 family. The CD3 family of myeloid immunoglobulin receptors includes activating ( CD3b, CD3e ) and inhibitory members ( CD3a, CD3f ), as well as molecules presenting a negative charge within their transmembrane domain ( CD3c, CD3d ). CD3A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.It contains oneIg-like V-type ( immunoglobulin-like ) domain. CD3A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD3c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD3c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD3a and CD3c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).

        CD300A の参考文献

        • Bachelet,I. et al., 2005, J. Immunol. 175:7989-7995.
        • Bachelet,I. et al., 2008, J Immunol. 180 (9):6064-9.
        • Ju,X. et al., 2008, Blood. 112 (4):1184-94.
        • Martínez-Barriocanal,A. et al., 2010, J Biol Chem. 285 (53):41781-94.
        • Lankry,D. et al., 2010, J Immunol. 185 (5):2877-86.

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