CD204/MSR1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

MSR1 (Macrophage Scavenger Receptor 1, also known as SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII), located on 8p22, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog. The gene produces a 49762 Da protein composed of 451 amino acids. This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. Diseases such as Barrett Esophagus and Non-Alcoholic Fatty Liver Disease are associated with MSR1. The related pathways of MSR1 include A-beta Uptake and Degradation and Binding and Uptake of Ligands by Scavenger Receptors.

CD204/MSR1 Protein (4)

    CD204/MSR1 Antibody (10)

      CD204/MSR1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      CD204/MSR1 cDNA Clone (28)

      NM_138715.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      L04274.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001191939.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD204/MSR1 Lysate (4)

        CD204/MSR1 の背景知識

        Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

        CD204/MSR1 の参考文献

        • Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
        • Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
        • Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
        • Sun J. et al., 2006, Prostate. 66 (7): 728-37.

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