CD200RLa Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD200RLa reagents are produced in house and quality controlled, including 10 CD200RLa Antibody, 1 CD200RLa ELISA, 13 CD200RLa Gene, 3 CD200RLa Lysate, 3 CD200RLa Protein, 1 CD200RLa qPCR. All CD200RLa reagents are ready to use.

CD200RLa Protein (3)

    CD200RLa Antibody (10)

      CD200RLa ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      CD200RLa cDNA Clone (13)

      NM_001008784.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD200RLa qPCR Primer (1)

      CD200RLa Lysate (3)

        CD200RLa の背景知識

        Cell surface glycoprotein CD2 receptor 2, also known as Cell surface glycoprotein CD2 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD2 receptor-like 2, CD2Rla, CD2R1L and CD2R2, is a single-pass type I membrane protein which belongs to theCD2R family. CD2R1L / CD2R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD2 is a transmembrane protein delivering immunoregulatory signals after engagement of CD2R. A family of CD2Rs exist ( CD2R1, CD2R2, CD2R3, CD2R4 ) with different tissue expression and functional activity. In the presence of anti-CD2R2 / CD2R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD2 and one of its receptors, CD2R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD2R1, anti-CD2R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.

        CD200RLa の参考文献

        • Wright G.J., et al.,(2003), Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171:3034-3046.
        • Gorczynski R.M., et al., (2004), Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.Am. J. Reprod. Immunol. 52:147-163.
        • Muzny D.M., et al.,(2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.

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