CD1 is a family of proteins structurally related to major histocompatibility complex (MHC) molecules and specialized in presenting lipids or glycolipids to T cells. In humans, there are five CD1 genes (CD1A to CD1E). CD1E and CD1A genes may be involved in networks which determine susceptibility to RR-MS and PP-MS, respectively. CD1A and CD1E polymorphisms contribute to the polygenic susceptibility to MS. It's a possible role of CD1E polymorphisms in malaria protection among school children and that CD1e molecules are involved in anti-malarial immunity.