CD16a Proteins, Antibodies, cDNA Clones Research Reagents

All CD16a reagents are produced in house and quality controlled, including 16 CD16a Antibody, 18 CD16a Gene, 1 CD16a IP Kit, 7 CD16a Lysate, 10 CD16a Protein, 2 CD16a qPCR. All CD16a reagents are ready to use.

CD16a Protein (10)

    CD16a Antibody (16)

      CD16a cDNA Clone (18)


      クローニングベクター cDNA 製品

      In expression vector

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      CD16a qPCR Primer (2)

      CD16a Lysate (7)

        CD16a の背景知識

        The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

        CD16a の参考文献

        • David Dornan, et al. Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood. 2010 116: 4212-4222

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