CD146/MCAM Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD146/MCAM reagents are produced in house and quality controlled, including 22 CD146/MCAM Antibody, 2 CD146/MCAM ELISA, 26 CD146/MCAM Gene, 3 CD146/MCAM Lysate, 3 CD146/MCAM Protein, 2 CD146/MCAM qPCR. All CD146/MCAM reagents are ready to use.

CD146/MCAM Protein (3)

    CD146/MCAM Antibody (22)

      CD146/MCAM ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      CD146/MCAM cDNA Clone (26)

      NM_006500.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_023061.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD146/MCAM Lysate (3)

        CD146/MCAM の背景知識

        The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

        CD146/MCAM の参考文献

        • Mills L, et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-14.
        • Taira E, et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-87.
        • Fritzsche FR, et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-64.
        • Bidlingmaier S, et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-7.
        • Boneberg EM, et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-31.

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