CD133/PROM1 Proteins, Antibodies, cDNA Clones Research Reagents

All CD133/PROM1 reagents are produced in house and quality controlled, including 2 CD133/PROM1 Antibody, 28 CD133/PROM1 Gene, 2 CD133/PROM1 Lysate, 2 CD133/PROM1 Protein, 2 CD133/PROM1 qPCR. All CD133/PROM1 reagents are ready to use.

CD133/PROM1 Protein (2)

    CD133/PROM1 Antibody (2)

      CD133/PROM1 cDNA Clone (28)

      BC012089

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008935.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001110137.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD133/PROM1 Lysate (2)

        CD133/PROM1 の背景知識

        CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.

        CD133/PROM1 の参考文献

        • Corbeil D. et al., 2001, Biochem Biophys Res Commun. 285 (4): 939-44.
        • Horn PA. et al., 1999, Blood. 93 (4): 1435-37.
        • Sanai N. et al., 2005, N Engl J Med. 353 (8): 811-22.

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