CD122/IL2RB Proteins, cDNA Clones Research Reagents

All CD122/IL2RB reagents are produced in house and quality controlled, including 65 CD122/IL2RB Gene, 11 CD122/IL2RB Lysate, 11 CD122/IL2RB Protein, 3 CD122/IL2RB qPCR. All CD122/IL2RB reagents are ready to use.

CD122/IL2RB Protein (11)

    CD122/IL2RB cDNA Clone (65)

    NM_000878.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008368.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_013195.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_002798371.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_003431504.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    CD122/IL2RB Lysate (11)

      CD122/IL2RB の背景知識

      Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B22+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.

      CD122/IL2RB の参考文献

      • Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.
      • Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8.
      • Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.

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