CD10 Proteins, Antibodies, cDNA Clones Research Reagents

MME (Membrane Metalloendopeptidase, also known as NEP; SFE; CD10; CALLA; CMT2T; SCA43), located on 3q25.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). Diseases such as Charcot-Marie-Tooth Disease, Axonal, Type 2T, and Spinocerebellar Ataxia 43 are associated with MME. The related pathways of MME include Collagen chain trimerization and Peptide hormone metabolism.

CD10 Protein (6)

    CD10 Antibody (9)

      CD10 cDNA Clone (52)

      NM_007289.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001289463.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012608.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_002802963.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      CD10 Lysate (6)

        CD10 の背景知識

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. The cluster of differentiation 10 (CD10), also known as Neprilysin and neutral endopeptidase, is a member of the CD system. CD10 is a zinc-dependent metalloprotease enzyme that had the function to degrade some small secreted peptides such as the amyloid beta-peptide. It exists as a membrane-bound protein and has a high concentration in kidney and lung tissues. Mutations in the CD10 gene can induce the familial forms of Alzheimer's disease, providing strong evidence for the protein's association with the Alzheimer's disease process. CD10 is also associated with other biochemical processes.

        CD10 の参考文献

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
        • Dogan, et al. (2000) CD10 and BCL-6 Expression in Paraffin Sections of Normal Lymphoid Tissue and B-Cell Lymphomas. American Journal of Surgical Pathology. 24(6): 846-52.

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