CBX2 Antibodies, cDNA Clones Research Reagents

All CBX2 reagents are produced in house and quality controlled, including 1 CBX2 Antibody, 15 CBX2 Gene, 1 CBX2 qPCR. All CBX2 reagents are ready to use.

CBX2 Antibody (1)

    CBX2 cDNA Clone (15)

    BC004252

    クローニングベクター cDNA 製品

    In lentiviral vector

    CBX2 qPCR Primer (1)

    CBX2 の背景知識

    Polycomb group (PcG) proteins regulate transcription, playing a key role in stemness and differentiation. Deregulation of PcG members is known to be involved in cancer pathogenesis. Emerging evidence suggests that CBX2, a member of the PcG protein family, is overexpressed in several human tumors, correlating with lower overall survival. Knock-down of CBX2 expression promotes neurite development, while overexpression of CBX2 inhibits neurite development. CBX2 is a direct target gene of miR-124. During neuronal differentiation, CBX2 was decreased while miR-124 was increased. The neuron-specific GAP-43 gene could contribute to the stimulating effect on neurite development associated with inhibition of CBX2. Chromobox 2 (CBX2), a component of polycomb repressive complex 1 (PRC1), binds lysine 27-methylated histone H3 (H3K27me3) via its chromodomain (CD) and plays a critical role in repressing developmentally regulated genes. Cbx2 may present a novel biomarker for predicting the prognosis of breast cancer patients. Cbx2 may also represent a potential target for treatment due to its important function in Taxol treatment responses.

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