Cathepsin S Proteins, Antibodies, cDNA Clones Research Reagents

All Cathepsin S reagents are produced in house and quality controlled, including 4 Cathepsin S Antibody, 52 Cathepsin S Gene, 3 Cathepsin S Lysate, 3 Cathepsin S Protein, 3 Cathepsin S qPCR. All Cathepsin S reagents are ready to use.

Cathepsin S Protein (3)

    Cathepsin S Antibody (4)

      Cathepsin S cDNA Clone (52)

      NM_004079.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      AF038546.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_021281.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC059142.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Cathepsin S Lysate (3)

        Cathepsin S の背景知識

        Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Compared with other lysosomal cysteine proteases, cathepsin S has displayed some unique characteristics. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, although direct evidence is still lacking, in its secreted form cathepsin S is implicated in degradation of the extracellular matrix, which may contribute to the pathology of a number of diseases, including arthritis, atherosclerosis, neurological diseases and chronic obstructive pulmonary disease.

        Cathepsin S の参考文献

        • Liu W, et al. (2004) Cysteine protease cathepsin S as a key step in antigen presentation. Drug News Perspect. 17(6): 357-63.
        • Thurmond RL, et al. (2005) Cathepsin S inhibitors as novel immunomodulators. Curr Opin Investig Drugs. 6(5): 473-82.
        • Wang DM, et al. (2008) Cathepsin S in pathogenesis of neurological diseases. Zhejiang Da Xue Xue Bao Yi Xue Ban. 37(4): 422-6.

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