CASPR2 Proteins, Antibodies, cDNA Clones Research Reagents

All CASPR2 reagents are produced in house and quality controlled, including 4 CASPR2 Antibody, 4 CASPR2 Gene, 1 CASPR2 Lysate, 1 CASPR2 Protein, 1 CASPR2 qPCR. All CASPR2 reagents are ready to use.

CASPR2 Protein (1)

    CASPR2 Antibody (4)

      CASPR2 cDNA Clone (4)

      NM_014141.5

      In expression vector

      In lentiviral vector

      CASPR2 qPCR Primer (1)

      CASPR2 Lysate (1)

        CASPR2 の背景知識

        CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.

        CASPR2 の参考文献

        • Poot M, et al. (2010) Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder. Neurogenetics. 11(1): 81-9.
        • Friedman JI, et al. (2008) CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Mol Psychiatry. 13(3): 261-6.
        • Verkerk AJ, et al. (2003) CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics. 82(1): 1-9.

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