CARHSP1 Proteins, Antibodies, cDNA Clones Research Reagents

All CARHSP1 reagents are produced in house and quality controlled, including 3 CARHSP1 Antibody, 30 CARHSP1 Gene, 1 CARHSP1 IP Kit, 1 CARHSP1 Protein, 1 CARHSP1 qPCR. All CARHSP1 reagents are ready to use.

CARHSP1 Protein (1)

    CARHSP1 Antibody (3)

      CARHSP1 cDNA Clone (30)

      BC003366

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_025821.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CARHSP1 qPCR Primer (1)

      CARHSP1 の背景知識

      CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogenic gene expression. CARHSP1 is regulated by nutrient status in the liver and functions at the transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase catalytic subunit (G6Pc) and phosphoenolpyruvate carboxykinase 1 (PEPCK1). In addition, it is found that CARHSP1 can physically interact with peroxisome proliferator-activated receptor-α (PPARα) and inhibit its transcriptional activity. Both pharmacological and genetic ablations of PPARα attenuate the inhibitory effect of CARHSP1 on gluconeogenic gene expression in hepatocytes.

      CARHSP1 の参考文献

      • Wistow G. et al., 2002, Mol Vis. 8: 205-20.
      • Wishart MJ. et al., 2002, Proc Natl Acad Sci. 99 (4): 2112-7.
      • Groblewski GE. et al., 1998, J Biol Chem. 273 (35): 22738-44.
      • Fan Y. et al., 2011, J Biol Chem. 286 (47): 40584-94.

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