Canf4 Proteins Research Reagents

All Canf4 reagents are produced in house and quality controlled, including 1 Canf4 Lysate, 1 Canf4 Protein. All Canf4 reagents are ready to use.

Canf4 Protein (1)

    Canf4 Lysate (1)

      Canf4 の背景知識

      Dog dander is an important cause of respiratory allergy but its content of allergenic components is still incompletely known. The size and the amino acid composition of the ligand-binding pocket indicate that Can f 4 is capable of binding only relatively small hydrophobic molecules which are different from those that Can f 2 is able to bind. The crystal structure of Can f 4 contained both monomeric and dimeric forms of the allergen, suggesting that Can f 4 is able to form transient (weak) dimers. The existence of transient dimers in solution was confirmed by use of native mass spectrometry. The dimeric structure of Can f 4 is formed when the ends of four β-strands are packed against the same strands from the second monomer.

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