OARD1 (O-Acyl-ADP-Ribose Deacylase 1, also known as TARG1, C6orf130) is a Protein Coding gene. The OARD1 gene, located on 6p21.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, and mosquito. The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product can inhibit these reactions through a competitive feedback loop. TARG1/C6orf130 is a macrodomain protein that hydrolyzes mono-ADP-ribosylation and interacts with poly-ADP-ribose chains. Diseases associated with OARD1 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Hypercholesterolemia, Familial, 4. 235 organisms have orthologs with human gene OARD1.