C6orf130 Antibodies, cDNA Clones Research Reagents

OARD1 (O-Acyl-ADP-Ribose Deacylase 1, also known as TARG1; C6orf130; dJ34B21.3), located on 6p21.1, is a Protein Coding gene. The gene produces a 17025 Da protein composed of 152 amino acids. C6ORF130 is a deacylase that converts O-acetyl-ADP-ribose, O-propionyl-ADP-ribose, and O-butyryl-ADP-ribose to ADP-ribose and acetate, propionate, and butyrate, respectively. The C6ORF130 macrodomain shares limited homology with the approximately 140-amino acid macrodomains of MACROD1 and MACROD2, but C6ORF130 lacks the extended N- and C-terminal sequences of these proteins.

C6orf130 Antibody (1)

    C6orf130 cDNA Clone (16)


    In expression vector


    クローニングベクター cDNA 製品

    In lentiviral vector

    C6orf130 の背景知識

    OARD1 (O-Acyl-ADP-Ribose Deacylase 1, also known as TARG1, C6orf130) is a Protein Coding gene. The OARD1 gene, located on 6p21.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, and mosquito. The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product can inhibit these reactions through a competitive feedback loop. TARG1/C6orf130 is a macrodomain protein that hydrolyzes mono-ADP-ribosylation and interacts with poly-ADP-ribose chains. Diseases associated with OARD1 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Hypercholesterolemia, Familial, 4. 235 organisms have orthologs with human gene OARD1.

    C6orf130 の参考文献

    • Rosenthal F, et al. (2013) Macrodomain-containing proteins are new mono-adp-ribosylhydrolases. Nat Struct Mol Biol 20 (4): 502-507.
    • Peterson FC, et al. (2011) Orphan macrodomain protein (human c6orf130) is an o-acyl-adp-ribose deacylase: Solution structure and catalytic properties. J Biol Chem 286 (41): 35955-35965.
    • Bütepage M, et al. (2018) Nucleolar-nucleoplasmic shuttling of targ1 and its control by DNA damage-induced poly-adp-ribosylation and by nucleolar transcription. Sci Rep 8 (1): 6748.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.