c-Myc/MYC Antibodies, cDNA Clones Research Reagents

MYC (MYC Proto-Oncogene, BHLH Transcription Factor, also known as MRTL; MYCC; c-Myc; bHLHe39), located on 8q24.21, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 48804 Da protein composed of 439 amino acids. This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability.

c-Myc/MYC Antibody (1)

    c-Myc/MYC cDNA Clone (15)

    NM_002467.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    c-Myc/MYC qPCR Primer (1)

    c-Myc/MYC の背景知識

    MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. MYC is one of the most important oncogenes in cancer. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. It is widely expressed in the gall bladder, esophagus, and other tissues. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.

    c-Myc/MYC の参考文献

    • Ding X, et al., 2009, PLoS One. 4(6): e5949.
    • Ratsima H, et al., 2011, Proc Natl Acad Sci. 108(43): E914-23.
    • Chiang YJ, et al., 2013, PLoS One. 8(4): e61761.

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