BTN2A2 cDNA Clones Research Reagents

All BTN2A2 reagents are produced in house and quality controlled, including 13 BTN2A2 Gene, 1 BTN2A2 qPCR. All BTN2A2 reagents are ready to use.

BTN2A2 cDNA Clone (13)

BC017497

クローニングベクター cDNA 製品

In lentiviral vector

BTN2A2 qPCR Primer (1)

BTN2A2 の背景知識

The human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity. To address this, Btn2a2-deficient mice are generated. Btn2a2−/− mice exhibited enhanced effector CD4+ and CD8+ T cell responses, impaired CD4+ regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis. Altered immune responses were attributed to Btn2a2 deficiency in antigen-presenting cells rather than T cells or nonhematopoietic cells. These results provide the first genetic evidence that BTN2A2 is a co-inhibitory molecule that modulates T cell–mediated immunity.

BTN2A2 の参考文献

  • Sarter K, Leimgruber E, Gobet F, et al. Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes. The Journal of Experimental Medicine. 2016;213(2):177-187.

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