BMPRIB Proteins, Antibodies, cDNA Clones Research Reagents

All BMPRIB reagents are produced in house and quality controlled, including 4 BMPRIB Antibody, 39 BMPRIB Gene, 3 BMPRIB Lysate, 3 BMPRIB Protein, 3 BMPRIB qPCR. All BMPRIB reagents are ready to use.

BMPRIB Protein (3)

    BMPRIB Antibody (4)

      BMPRIB cDNA Clone (39)

      NM_001203.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_007560.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001024259.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      BMPRIB Lysate (3)

        BMPRIB の背景知識

        BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 5-55 kD and type II receptors of about 7-8 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

        BMPRIB の参考文献

        • Ide H, et al. (1998) Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23--q24 byin situ hybridization and radiation hybrid map ping. Cytogenet. Cell Genet. 81(3-4): 285-6.
        • Mishina Y, et al. (2004) Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 279(26): 27560-6.
        • Yoon BS, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci. 102(14): 5062-7.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.