BMP7 Antibodies, cDNA Clones Research Reagents

All BMP7 reagents are produced in house and quality controlled, including 1 BMP7 Antibody, 26 BMP7 Gene, 3 BMP7 qPCR. All BMP7 reagents are ready to use.

BMP7 Antibody (1)

    BMP7 cDNA Clone (26)

    NM_001719.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001191856.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    BMP7 の背景知識

    BMP-7 (Bone morphogenetic protein 7), also known as osteogenic protein 1 (OP-1), is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys and bladder. BMP-7 may be involved in bone homeostasis. Osteogenic protein 1 plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. The expression of BMP-7 causes ventral phenotypes while its complete inhibition creates a dorsal phenotype. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.

    BMP7 の参考文献

    • Shi J. et al., 2010, Fertil Steril. 93(4): 1273-9.
    • González EA. et al., 2002, Kidney Int. 61(4): 1322-31.
    • Gould SE. et al., 2002, Kidney Int. 61(1): 51-60.
    • Hahn GV. et al., 1992, Genomics. 14(3): 759-62.

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